Sustainable Radical Approaches for Cross Electrophile Coupling to Synthesize Trifluoromethyl- and Allyl- tert-Alcohols

Abstract

Trifluoromethyl molecules have gained privileged recognition among the medicinal and pharmaceutical chemists. Sustainable photoredox- and electrochemical processes were employed to facilitate the relatively less explored radical cross electrophile coupling to access trifluoromethyl- and allyl-tertiary alcohols. Reactions proceed through trifluoromethyl ketyl radical and allyl radical intermediates which undergo challenging cross radical-radical coupling. The developed transformations are mild and chemo-selective to give cross coupled products and deliver a wide range of valuable trifluoromethyl and allyl containing tertiary alcohols. Both processes can also be applied for the synthesis of amine variant containing trifluoromethyl and allyl moiety which is considered as amide bioisostere.