Abstract
This paper assessed the collagen glue (Col) from rabbit skin for use as a raw material in combination with different water-based dispersants of antimicrobial agents such as ZnO NPs, TiO2 NPs doped with nitrogen and Ag NPs (TiO2-N-Ag NPs), and chitosan (CS) for the production of biocompatible and antimicrobial nanofibers. The electrospun nanofibers were investigated by scanning electron microscopy (SEM), attenuated total reflectance in conjunction with Fourier-transform infrared spectroscopy (ATR-FT-IR) analyses and antioxidant activity. The biocompatibility of electrospun nanofibers was investigated on cell lines of mouse fibroblast NCTC (clone L929) using MTT test assays. Antimicrobial activity was performed against Escherichia coli and Staphylococcus aureus bacteria and Candida albicans pathogenic fungus. Electrospun antimicrobial nanofibers based on collagen glue achieved reduction in the number of viable microorganisms against both fungi and bacteria and exhibited multiple inhibitory actions of fungal and bacterial strains. The electrospun nanofibers showed average dimension sizes in the range of 30–160 nm. The results indicated that both Col/TiO2-N-Ag NPs and Col/CS formulations are suitable for cell proliferation and may be useful for producing of nonactive wound dressings.
Highlights
Nowadays, food and leather industry activities generate an increase in potential pollutants by-products including rabbit skins
The present paper aims to develop new electrospun antimicrobial nanofibers based on collagen glue obtained from rabbit skin loaded with nonactive antimicrobial agents, as a sustainable and cost-effective material for potential medical wound dressings
In this paper new electrospun nonactive nanofibers based on rabbit skin collagen glue loaded with commercial ZnO NPs, TiO2 -N-Ag NPs, and CS antimicrobial agents have been prepared and characterized
Summary
Food and leather industry activities generate an increase in potential pollutants by-products including rabbit skins. Rabbit skins are treated as a by-product generated from meat processing, as a great source of gelatin over fish to replace other mammalian sources [1], with potential value in the packaging of meat products [2]. Our team reported for first time the obtaining of bioactive nanofibers based on collagen rabbit glue with the potential for tissue engineering applications [6]. Antibacterial nanofibers for wound dressing indicate a potential approach for progress of advanced, biologically active dressings compared to commercial dressings, as a result of great surface area to Materials 2020, 13, 5388; doi:10.3390/ma13235388 www.mdpi.com/journal/materials
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