Abstract
The quinoxaline (Qx) nucleus is present in various bioactive molecules. Thus, synthesis of Qxs continues to draw the attention of synthetic organic/medicinal chemists. The contemporary interest in search for newer synthetic methods for this privileged class of compounds remains unabated and a vast number of publications continue to appear. The focus of this chapter is on the research works published in this area after the year 2000 with the inherent objective to attain sustainability towards the synthesis. The attention will be on the key sustainable approaches of pharmaceutical industries like the solvent-free reactions, use of alternate reaction media (e.g., water, fluorous alcohols, polyethylene glycols, and ionic liquids), and alternate modes of synthesis such as microwave-assisted synthesis and flow reactions.
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