Abstract
Development of nanostructured textile material using sustainable finishing route and to evaluate its performance in the areas like wound management is challenging task. Stable and eco-friendly o/w nanoemulsion of tetrahydroxy curcumin derivative was developed by using high pressure homogenization method. The stable nanoemulsion for the selected drug was developed and evaluated for appearance, particle size distribution (100–300 nm), zeta potential (− 30.1 to − 31.1 mV) and drug content (80–83.3%). Nanoemulsion containing antimicrobial drug were impregnated on the textile material by exhaust methods using β-cyclodextrin and polycarboxylic acid as a crosslinking agent. Treated textile material is evaluated for its antimicrobial activity against standard antimicrobial strip using both AATCC 147 and AATCC 100, treated samples shows positive results against both positive and negative bacteria. Current eco-friendly technique would be innovative step towards development of medical textile for wound care applications.
Highlights
In the last few years, health care professionals have faced with an increasing number of patients suffering from various skin related diseases such as wound, burn injuries and which are really difficult to treat and heal
It was observed that nanoemulsion droplets have a uniform distribution with a mean particle size of 199.5 nm for blank Nanoemulsion batch, 217 nm for drug loaded batch before homogenization and 101.9 nm for optimized drug loaded batch after homogenization respectively
The zeta potential was found − 30.1 ± 0.1 (Fig. 3), it confirms that the formulated nanoemulsion is stable at room temperature which helps to avoid separation of aqueous and organic phase when loaded tetra hydroxy curcumin
Summary
In the last few years, health care professionals have faced with an increasing number of patients suffering from various skin related diseases such as wound, burn injuries and which are really difficult to treat and heal. The number of functional textiles with an antimicrobial activity incorporating both synthetic and biopolymers has increased considerably over the last few years. The synthetic antimicrobial agents are very effective against a range of microbes and give a durable effect on textiles; they are a cause of concern due to the associated side effects, such as action on non-target and microorganisms and water pollution. There is a great demand for antimicrobial textiles based on eco-friendly agents which help to reduce effectively the ill effects associated due to microbial growth on textile material and comply with statutory requirements imposed by regulating agencies (Gotmare and Kole 2017). Textile materials treated with natural products will perhaps be the largest application in the area of medical textiles
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