Abstract
It was important to find out the suitable animal which is a laboratory animal and susceptible to M. leprae, and Kohsaka et al. previously reported the establishment of experimental lepromatous leprosy with congenitally athymic nude mouse.It was interested to use rhino mouse which is an immune-deficient animal with disappearance of thymus in early stage, therefore, an attempt to inoculate M. leprae into the rhino mouse was carried out.Eight- and five-month old rhino mice (rhrh) of genetic background A/H were inoculated with Mycobacterium leprae in order to find out another model of exprimental lepromatous leprosy with laboratory animal other than nude mouse. All of inoculated rhino mice indicated the multiplication of the bacilli in the foot pads at the site of inoculation bacteriologically and histopathologically even though the proliferation was not so remarkable as in nude mouse.Rhino mouse could survive for more than 15 months under conventional circumstances, but there is no significant proliferation of M. leprae in the mouse as compeared to nude mouse, and it is suggested that rhino mouse is not so useful for leprosy research because of the difficulties of its rearing and breeding.
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