Susceptibility gene research of coronary artery lesions in Kawasaki disease

Abstract

Kawasaki disease is an acute and systemic vasculitis of small and medium-sized arteries, which often occurs in children under 5 years old.The etiology and pathogenesis of Kawasaki disease remain unclear.Epidemiological data have shown the incidence in Asian population is higer than that in non-Asian population.Coronary artery lesions are the most serious complications in children with Kawasaki disease, which can result in ischemic cardiomyopathy, myocardial infarction or sudden death.Coronary artery lesions occur in about 25% untreated children and in 5% treated children.In recent years, replacing rheumatic fever, it has been the leading cause of acquired heart disease in children in developed countries.Current research on coronary artery lesions is a hotspot of Kawasaki disease, and genetic factors play an important role in the development of the lesions.Studies show that genes such as ITPCK, CASP3, TNF-α, CD40, IL-10, PELI1, GRIN3A, CTLA-4, SNX24, LRP1B are closely related to coronary artery lesions.In this article, we review some susceptibility genes on coronary arterial lesions in Kawasaki disease. Key words: Kawasaki disease; Coronary artery lesion; Gene