Survivors of uterine cancer empowered by exercise and healthy diet (SUCCEED): A randomized controlled trial

Abstract

ObjectiveThe majority of endometrial cancer survivors (ECS) are obese and at risk for premature death. The purpose of this study was to evaluate an intervention for ECS to promote weight loss and a healthy lifestyle. MethodsEarly stage overweight and obese (body mass index ≥25) ECS (N=75) were randomized to a 6-month lifestyle intervention (LI) or usual care (UC). The LI group received education and counseling for six months (10 weekly followed by 6 bi-weekly sessions). Weight change at 12months was the primary endpoint. Secondary outcomes included fruit/vegetable servings/day and physical activity (PA). Multiple imputations were used for missing data and mixed models were used to analyze changes from baseline. ResultsAdherence was 84% and follow-up data were available from 92% of participants at 6months and 79% at 12months. Mean [95% CI] difference in weight change between LI and UC groups at 6months was −4.4kg [−5.3, −3.5], p<0.001 and at 12months was −4.6kg [−5.8, −3.5], p<0.001. Mean [95% CI] difference in PA minutes between groups at 6months was 100 [6, 194], p=0.038 and at 12months was 89 [14, 163], p=0.020. Mean difference in kilocalories consumed was −217.8 (p<0.001) at 6months and −187.2 (p<0.001) at 12months. Mean [95% CI] difference in fruit and vegetable servings was 0.91servings/day at 6months and 0.92 at 12months (p<0.001). ConclusionsBehavior change and weight loss are achievable in overweight and obese ECS, however, the clinical implications of these changes are unknown and require a larger trial with longer follow-up.