Abstract
Objective: Survivin is regarded as the most robust antiapoptosis protein that has been implicated in both control of cell division and inhibition of apoptosis, and its over-expression in epithelial ovarian cancer (EOC) is associated with chemoresistance and poor survival. In the previous study, we suggested that piperlongumine induced apoptosis and synergized with cisplatin or paclitaxel in human ovarian cancer cells in vitro. Here, we investigate the functional impacts of piperlongumine on survivin expression in EOC cells and delineate its mechanism of action.
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