Abstract
e18164 Background: Malignant mesothelioma is a highly aggressive tumor arising from the mesothelial surface. Treatment for malignant mesothelioma has not changed significantly in recent years. Better patient care may have improved survival in malignant mesothelioma patients. We conducted this study to evaluate the relative survival rates in elderly patients with malignant mesothelioma over the last one and half decades in the United States. Methods: Elderly patients (age≥65 years) diagnosed with malignant mesothelioma were selected from the Surveillance, Epidemiology, and End Results (SEER-18) database. We used Z-test to compare 1- year relative survival rates (RS) between the two time frames: 2000-2009 and 2010-2014. Several cohorts categorized by race (Caucasians and African-Americans) and gender were stratified. The survival rates were accompanied by standard errors. Results: In total, the SEER-18 database identified 6,346 patients (4,210 from 2000-2009 and 2,136 from 2010-2014; 78.3% were males, 92.6% were Caucasians). Overall, there was no improvement in survival in recent years (1-year RS: 35.4 ± 0.8 vs 36.5 ± 1.2, Z score = 1.910 on 2000-2009 & 2010-2014 respectively). This was true for most of the cohort including those for males: 1-year RS: 35.0±0.9 vs 36.1±1.3, Z score = 1.569; females: 1-year RS: 37.0±1.7 vs 37.8±2.5, Z score = 1.116 and Caucasians: 1-year RS: 35.8± 0.8 vs 36.6.± 1.2, Z score = 1.512 on 2000-2009 & 2010-2014 respectively. There was significant improvement in relative survival among African Americans: 1-year RS: 25.3±3.6 vs 38.6±5.6, Z score = 2.362. Conclusions: Our analysis of real-world data showed an improvement in relative survival rates for African American patients with malignant mesothelioma in recent years. This is likely related to improved delivery of care. Overall prognosis continues to remain poor and there is a strong need for novel therapeutic agents.
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