Survival Stratification Pattern of Colorectal Carcinoma with CEA MMP-2 and p27kip1 Expression

Abstract

The prognosis varies greatly in colorectal caner (CRC) patients, even in the same stage. We examined the correlation between the expression of a reportedly wide range of biomarkers (MMP-2, CEA, p27kip1, β-catenin, CDC25B, Mucin-1, VEGF-D, c-erbB-2/neu, TGF-α and C-met) and clinicopathological features in CRC patients in order to identify a panel of biomarkers predictive of CRC prognosis. The expressions of these ten individual biomarkers in 127 CRC were analyzed by immunohistochemistry method. Univariate and multivariate analysis were done to analyze these biomarkers expression with the disease free survival time in CRC. Among markers studied, high expression of MMP-2, CEA and low expression of p27kip1 are significantly related to poor prognosis in univariate analysis. The expression of MMP-2, CEA, p27kip1, TNM staging, and differentiation are independent prognostic factors for survival by Cox regression analysis. The coexpression pattern of MMP-2, CEA and p27kip1 MCP has significant prognostic value in all patients. Cox regression reveals that coexpression pattern of MMP-2, p27kip1 and CEA, TNM stage and differentiation are independent prognostic factors in CRC. Though prognosis in patients with CRC is difficult to predict, the results of this study provide further evidence that the combination of biomarkers of MMP-2, CEA and p27kip1, or MCP, is more informative than any single tumor biomarker alone for the survival stratification of CRC. MCP may be a useful marker for clinical management and may provide multiple targets for therapeuticintervention.