Abstract
The paper reassesses a survival at tumor recurrence in soft matter. First, the stability of structural motifs under shear in clusters of dipolar spheres is characterized. Next, there are introduced transitions between polymer knots and rhythms of these transitions are obtained. The sensor is built for these rhythms. Treatment, with a tensile force protocol, is modeled, when the tumor in soft matter is observed by the above sensor. Survival probability, at tumor recurrence in soft matter, is defined for the treatment with a tensile force protocol. It is stated that the survival probability at a tensile force protocol treatment in soft matter confirms or specifies the prognostic survival of 32 patients with breast cancer.
Highlights
Cancer is a multi-step process, where normal cells become transformed, grow, and may disseminate to establish new lesions in the body [1]
It is stated that the survival probability at a tensile force protocol treatment in soft matter confirms or specifies the prognostic survival of 32 patients with breast cancer
In a tumor microenvironment, there is physical energy, enabling for: 1) intracellular signaling by molecular vibration [4] [5]; 2) interplay between the circadian
Summary
Cancer is a multi-step process, where normal cells become transformed, grow, and may disseminate to establish new lesions in the body [1]. The physical properties of individual cells and of the tissue microenvironments are potent determinants of cancer progression. Morphology, and migration are physical traits, linked to gene expression changes, which affect metastatic seeding, organ selectivity, and tumor growth [1] [2]. The tumor recurrence is understood as complex tumor dynamics in soft matter, modeling the upper physical qualities of individual cells and tissue microenvironment. In this case, the tumor in soft matter is defined as a structural motif, and the cyclic chemotherapy in soft matter, after which tumor recurrence occurs, is set as the restoration time
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