Survival prediction of LGG patients based on deep learning of MRI data and genomic data integration

Abstract

Low-grade gliomas (LGG) is the most common primary intracranial tumor, with high incidence rate, high recurrence rate, high mortality rate and low cure rate. Therefore, it is necessary to predict the survival of LGG patients in diagnosis. Considering the complementarity of information, the new proposed algorithm in this study is designed to integrate Magnetic Resonance Image (MRI) data and gene expression data using deep learning method to predict the Disease Specific Survival (DSS) of LGG patients. Firstly, MRI data of 44 patients is screened from TCIA database, and then the corresponding gene expression data of 44 patients is searched from TCGA database. Then, 724 image feature data extracted from MRI data are filtered and extracted by deep learning method, and DSS tags are used to train the model; deep learning method is used to extract 20530 features of gene expression data, and DSS tags are also used for training. As a contrast, the deep learning method is used to integrate the two features to train the model. Experiments are evaluated on MRI data, gene expression data and the integration data of MRI and gene expression data, respectively. The results show that by using the integration of MRI data and gene expression data performs better than using single data in terms of the time-dependent receiver operating characteristic(ROC) and the area under the curve (AUC) of the ROC curve criteria.