Survival outcomes of Asian younger men (< 55years) undergoing radical prostatectomy: a review of prostate cancer database in a tertiary hospital in Singapore.

Abstract

Prostate cancer largely affects older men. This study aims to investigate prostate cancer in younger men (< 55years) to shed light on the survival outcomes of this unique subset of patients in Asian context. Data were obtained from the Singapore General Hospital Prostate Cancer Registry. Data on all men with clinically organ confined prostate cancer who underwent radical prostatectomy between 1998 and 2016 were obtained from the registry. Tumor characteristics, follow-up data, and cause of death were acquired. A total of 1120 men underwent radical prostatectomy between 1998 and 2016. Of these, 12 were aged ≤ 44years, 106 were aged 45-54years, 596 were aged 55-64, 397 were aged 65-74 and 9 were aged ≥ 75. There was no difference across age groups when comparing Gleason ≤ 7 vs Gleason ≥ 8 disease, T1/2 vs T3/4 disease and the median PSA values were similar. No difference was observed in overall survival or prostate cancer specific survival among 4 age groups (≤ 44, 45-54, 55-64, 65-74) (p = 0.156 and p = 0.227 respectively). Although there was a trend of increasing rate of biochemical recurrence for older patients, it's not statistically significant (p = 0.157). Time to biochemical recurrence was similar as well (p = 0.257). This large cohort of Asian patients who underwent radical prostatectomy did not show significant age-related differences in important parameters and outcomes.