Abstract
BackgroundThe choice of surgical strategy for patients with rectal gastrointestinal stromal tumor (GIST) remains controversial. This study aims to address whether the surgical procedure [local excision (LE) vs. radical excision (RE)] influences the survival outcomes.MethodsThe information of the patients recruited in this study was obtained from the Surveillance, Epidemiology, and End Results (SEER) database. A survival curve was used to evaluate the differences in cancer-specific survival (CSS).ResultsNo significant difference was detected in the CSS between the LE and RE groups. Also, no significant differences were observed in the CSS between the two groups with respect to different T classification, N classification, tumor differentiation, tumor size, regional LN surgery, age, gender, race, chemotherapy, and radiotherapy. The T classification and age were independent prognostic factors in rectal GIST patients.ConclusionsLE and RE have similar survival time after surgery, and LE could be considered as an effective surgical approach for rectal GIST.
Highlights
The choice of surgical strategy for patients with rectal gastrointestinal stromal tumor (GIST) remains controversial
Rectal GIST is treated with radical excision (RE), including abdominoperineal excision and total pelvic exenteration, as RE is associated with low local recurrence [7]
A total of 154 patients with rectal GIST were obtained from SEER database from 1973–2015; 70 (45.5%) underwent local excision (LE) surgery and 84 (54.5%) underwent RE
Summary
The choice of surgical strategy for patients with rectal gastrointestinal stromal tumor (GIST) remains controversial. This study aims to address whether the surgical procedure [local excision (LE) vs radical excision (RE)] influences the survival outcomes. Rectal GIST is rare, accounting for about 5% of all GISTs [2], but the malignancy of GIST in the rectum is higher than that at other sites and related to poor prognosis [3, 4]. Local excision (LE) and radical excision (RE) are feasible for rectal GIST, and the selected surgical approach is mostly the subjective opinion of surgeons [6]. Rectal GIST is treated with RE, including abdominoperineal excision and total pelvic exenteration, as RE is associated with low local recurrence [7]. Lymph node (LN) metastasis is rare in GIST, and regional LN dissection is unnecessary [8, 9], deeming LE as a reasonable
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