Abstract
To assess the survival outcome and morbidity pattern after interval cytoreduction surgery done for FIGO stage III and IV epithelial ovarian cancer, not amenable to primary cytoreduction. This is a retrospective study of patients diagnosed with advanced-stage epithelial ovarian cancer who underwent interval cytoreduction from January 2014 to December 2016. Morbidity profile was assessed using descriptive statistics and Chi-square test for statistical significance. Overall and disease-free survival was calculated using Kaplan–Meier method and log-rank test for statistical significance. Postoperative complications were graded according to Clavien–Dindo grading system. Patients who attained OCR during ICR had better progression-free survival (PFS) at the end of 3 years compared to patients who could not achieve OCR during ICR (p = 0.014). There was no significant difference in OS between stages III and IV but stage III patients had better PFS comparing to stage IV patients (but p value was not significant). There was no significant postoperative morbidity after ICR. After neoadjuvant chemotherapy, OCR could be achieved in around 80% of advanced-stage epithelial ovarian cancer. At age less than 70 years, attainment of optimal cytoreduction during interval cytoreduction was associated with significant PFS at the end of 3 years.
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