Abstract
Spermatogonial stem cells, which survive a neutron dose of 150 rad, all belong to a radioresistant population, characterized in the present study by a D/sub 0/ value for neutrons of 96 +- 5 rad. Shortly after a dose of 150-rad neutrons the surviving stem cells greatly increased in radiosensitivity; at 24 h after this dose they were characterized by a D/sub 0/ of 25 +- 1 rad. At 8 days after 150 rad the D/sub 0/ value was higher; 46 +- 4 rad and it increased further to 54 +- 3 rad at 15 days. The increase in D/sub 0/ ceased between the 15th and 26th day after irradiation; at the latter time a D/sub 0/ of 49 +- 2 rad was found. These data show that during the first 26 days after a dose of 150-rad neutrons the radiosensitivity of the surviving stem cell population first increases and then slowly decreases to stay at a relatively high level of radiosensitivity from 15 days on without signs of a return to the preirradiation value. The stem cell population, although expanding after the first dose, did not return to its normal size within the period investigated.
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