Abstract
ObjectivesTo report real-world long-term survival of primary penetrating keratoplasty (PK) in the United States and analyze risk factors associated with failure. DesignRetrospective longitudinal cohort study using a large commercial insurance database. ParticipantsTen million patients enrolled in the database from 2011 to 2017 were identified using Current Procedural Terminology codes for PK. MethodsKaplan–Meier survival analysis was performed to determine failure rate and risk factors impacting graft outcomes. ResultsFive hundred and ninety-six primary PKs were identified. The 3-year survival was 78% (confidence interval [CI]: 73%–82%), 5-year survival was 76% (CI: 70%–80%), and 7-year survival was 73% (CI: 66%–79%). ConclusionThis study demonstrated a significantly lower 5-year success rate for primary PK performed for all causes than previously published case series in the United States.
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