Survival of patients with Ewing's sarcoma in Yazd-Iran.

Ali Akhavan,Fazllolah Ghanadi,Hadi Shamshiri,Fariba Binesh

doi:10.7314/apjcp.2014.15.12.4861

Ali Akhavan, Fazllolah Ghanadi + Show 2 more

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https://doi.org/10.7314/apjcp.2014.15.12.4861

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Abstract

The Ewing's sarcoma family is a group of small round cell tumors which accounts for 10-15% of all primary bone neoplasms. The aim of this study was to evaluate the survival of Ewing's sarcoma patients in our province and to determine of influencing factors. All patients with documented Ewing's sarcoma/ primitive neuroectodermal tumor(PNET) family pathology were enrolled in this study during a period of eight years. For all of them local and systemic therapy were carried out. Overall and event free survival and prognostic factors were evaluated. Thirty two patients were enrolled in the study. The median age was 17.5 years. Twenty (65.2%) were male and 9 (28.1%) were aged 14 years or less. Mean disease free survival was 26.8 (95%CI; 13.8-39.9) months and five year disease free survival was 26%. Mean overall survival was 38.7 months (95%CI; 25.9-50.6) and median overall survival was 24 months. Five year overall survival was 25%. From the variables evaluated , only presence of metastatic disease at presentation (p value=0. 028) and complete response (p value =0. 006) had significant relations to overall survival. Survival of Ewing's sarcoma in our province is disappointing. It seems to be mostly due to less effective treatment. Administration of adequate chemotherapy dosage, resection of tumor with negative margins and precise assessment of irradiation volume may prove helpful.

Highlights

Ewing’s sarcoma family are a group of small round cells tumors and consisting of Ewing’s sarcoma, peripheral primitive neuroectodermal tumor and Askin tumor (Lisa et al, 2013)
The Ewing’s sarcoma family is a group of small round cell tumors which accounts for 10-15% of all primary bone neoplasms
Materials and Methods: All patients with documented Ewing’s sarcoma/ primitive neuroectodermal tumor(PNET) family pathology were enrolled in this study during a period of eight years

Summary

Introduction

Ewing’s sarcoma family are a group of small round cells tumors and consisting of Ewing’s sarcoma, peripheral primitive neuroectodermal tumor and Askin tumor (Lisa et al, 2013). Materials and Methods: All patients with documented Ewing’s sarcoma/ primitive neuroectodermal tumor(PNET) family pathology were enrolled in this study during a period of eight years. 27.49-46.22) in the non-metastatic group.Five year to a retrospective study performed between 1997 to 2008 overall survival was 28% and 12% in non metastatic and at Shiraz University in the south of Iran, among the 426 metastatic patients respectively.From the variables, only patients with musculoskeletal tumors 28 (15.9%) patients presence of metastatic disease at presentation (p=0.028) had Ewing’s sarcoma (Solooki et al, 2011).

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