Survival of Mouse-Grown Rat Erythrocytes

Abstract

SummaryA study was made of survival of Cr51-labeled erythrocytes from irradiated mice that had been given rat bone marrow. Survival of these erythrocytes (mouse-grown rat erythrocytes) in both mice and rats was compared with survival of normal rat and normal mouse erythrocytes in mice and rats. The 50% survival time, i.e. the time when 50% of the initial radioactivity remained, of mouse-grown rat erythrocytes in the rat was 15 ± 2.5 days, and the 5% survival time, i.e. the time when 5% of the initial radioactivity remained, was 51 ± 4.5 days. Respective values for survival of normal rat erythrocytes in the rat were 18 ± 2.5 and 52 ± 4.5 days and for normal mouse erythrocytes in the rat, 2 and 3 days. The 50% survival time of mouse-grown rat and of normal rat erythrocytes in the mouse was 2 days and the 5% survival time was 3-4 days. Respective values for the survival of normal mouse erythrocytes in the mouse were 20 ± 2.5 and 49 ± 5.0 days. The data show that, by one physiological criterion, erythrocytes ...