Abstract
BackgroundPopulation-based studies on endometrial cancer providing survival estimates by age, histology, and stage have been sparse. We aimed to derive most up-to-date and detailed survival estimates for endometrial cancer patients in Germany.MethodsWe used a pooled German national dataset including data from 11 cancer registries covering a population of 33 million people. 30,906 patients diagnosed with endometrial cancer in 1997-2006 were included. Period analysis was performed to calculate 5-year relative survival (RS) in 2002-2006. Trends in survival between 2002 and 2006 were examined using model-based period analysis. Age-adjustment was performed using five age groups (15-44, 45-54, 55-64, 65-74, and 75+ years).ResultsOverall, age-adjusted 5-year relative survival in 2002-2006 was 81%. A moderate age gradient was observed, with 5-year RS decreasing from 90% in the age group 15-49 years to 75% in the age group 70+ years. Furthermore prognosis varied strongly by histologic subtypes and stage, with age-adjusted 5-year RS ranging from 43% (for sarcoma) to 94% (for squamous metaplasia), and reaching 91% for localized, 51% for regional, and 20% for distant stage. Except for age group 65-74 years, no significant improvement in survival was seen during the recent 5-year period under investigation.ConclusionIn this comprehensive population-based survival analysis of patients with endometrial cancer from Germany, prognosis of endometrial cancer moderately varied by age, and strongly varied by histology and stage. While prognosis is rather good overall, further improvement in 5-year relative survival of endometrial cancer patients has been stagnating in the early 21st century.
Highlights
Population-based studies on endometrial cancer providing survival estimates by age, histology, and stage have been sparse
Prognosis strongly varied by histology, with ageadjusted 5-year relative survival (RS) ranging from 43.1% to 94.3%
A moderate age gradient was observed, with 5-year RS decreasing from 90.0% in age group 15-49 years to 74.8% in age group 70+ years
Summary
Population-based studies on endometrial cancer providing survival estimates by age, histology, and stage have been sparse. We aimed to derive most up-to-date and detailed survival estimates for endometrial cancer patients in Germany. Endometrial cancer is generally associated with a favorable prognosis as most patients are diagnosed at early stages, most likely due to frequent postmenopausal vaginal bleeding, which enables timely diagnosis and commencement of therapy. Patients diagnosed at advanced stage have poor prognosis [7,8,9] and survival differs substantially for histologic types [8,10]. Population-based survival data by histology have been sparse worldwide, for Germany as they mostly relied on data from the Saarland Cancer Registry in the past, covering only 1.3% of the total German population [11]
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