Survival in uveal melanoma spanish patients: 1992‐2012

Abstract

AbstractPurpose To analize the specific survival of spanish patients diagnosed and treated of uveal melanoma in a national referral unit and compare the results with the previously published in other populationMethods Patients diagnosed of choroidal and ciliary body melanoma between 1992 and 2012 were included. Epidemiologic and general data, clinical and tumor characteristics, histopathologic features, survival status and cause of death were collected prospectively in a database. Statistical analysis was descriptive for baseline clinical features; survival was analysed by Kaplan‐Meier curves and multivariate Cox's regression model.Results 480 patients were included. Mean follow up of 58.6 months; mean age of 61.7 in males (48.5%) and 62.6 in females, arising in choroid 95.6%. Iris color was grey in 19%, and brown in 43.8%. Most of the tumors were medium size (40.4%) without neither extraocular (94.6%) nor systemic(98.7%) extension.Brachytherapy was performed in 43.4%, observation in 36.4% and enucleation in 18.2%. Predominant histologic types were mixed (39.1%) and fusiform (34.3%). Thirty nine patients died during the follow up time due to metastatic melanoma. Survival rate at 5 and 10 years was 87.7% and 85.5%. Patients with grey/blue iris presented worse survival at 5 years (75.6%) than hazel (91.4%). No deaths were registered in patients with small size; for medium and large survival was 91.2% and 64%. Factors with prognostic significance were: ciliary body location, extraocular extension, epithelioid type and grey/blue iris color.Conclusion The present study show a better survival than previously published series. Lighter iris color as showed prognostic value.These results may be due to epidemiologic differences.