Abstract

It will come as no surprise to most clinicians involved in the treatment of primary brain tumours that there is little evidence of improvement in outcome between the late 1980s and the late 1990s. The majority of these tumours are gliomas and in this group most are high-grade tumours, which are notorious for having resisted the therapeutic endeavours that have improved outcome in so many other cancers. It is only in the last few years that new insights into the biology of gliomas and significant changes in the treatment of these tumours has occurred, which we predict will alter the outcome in the coming decade.

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