Survival and prognosis after assisted ventilation for acute respiratory failure in cystic fibrosis

S Van Gestel,M Slieker,F Teding Van Berkhout,G Tramper,H Heijerman,K Jansen,K Van Der Ent

doi:10.1186/cc3285

Abstract

The use of mechanical ventilation for acute respiratory failure (ARF) in patients with cystic fibrosis (CF) has long been discouraged because of a poor outcome in this group of patients. However, new insights into ventilatory strategies and a better life expectancy per se in CF patients necessitate regular reevaluation of this attitude. The most recent studies report a mortality in adult CF patients requiring mechanical ventilation that varies widely between 45% and 80%. Results in children are reported as more favourable, but little is known about the long-term pulmonary outcome of children with CF who required mechanical ventilation for ARF already at a young age.

Highlights

Community-acquired pneumonia remains a common ventilation (MV) were randomized into two groups: one group was condition worldwide
This study shows that the inhibition of the intramyocardial expression of tumour necrosis factor (TNF)-α and of its secondary mediator COX-2 related to moderate hypothermia during cardiopulmonary bypass (CPB) is associated with the inhibition of p38 mitogen-activated protein kinase (MAPK)–acute pancreatitis (AP)-1, but not of the NF-κB pathway
Nominal values of inducible nitric oxide synthase (iNOS) detected by immunoassay were based upon calibration with commercial murine iNOS standards

Summary

Introduction

Community-acquired pneumonia remains a common ventilation (MV) were randomized into two groups: one group was condition worldwide. Methods Eighty-one consecutive patients (age 63 ± 16 years, male n = 51, SAPS 2 score 49 ± 11, mechanical ventilation n = 50, vasopressors n = 56, renal failure n = 19, postoperative n = 23) admitted to the ICU during a 3-month period were evaluated. Probiotics administration was suggested to reduce the incidence of infections and the overall morbidity and mortality in surgical patients The aim of this prospective randomized clinical trial was to assess the effects of a combination formula of probiotics and prebiotics (Synbiotic 2000Forte; Medifarm, Sweden) versus prebiotics only (fiber) in critically ill, long-term mechanically ventilated trauma patients. This study examines the acute patient outcomes associated with the evolution of early total care to damage control orthopaedics for multiply injured patients with femoral shaft fractures

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