Survival and pattern of tumor progression with yttrium-90 microsphere radioembolization in predominantly hepatitis B Asian patients with hepatocellular carcinoma.

Abstract

Intra-arterial yttrium-90 ((90)Y) microsphere radioembolization (RE) is an emerging treatment option with good outcomes reported predominantly in hepatitis C Western populations with hepatocellular carcinoma (HCC). We report outcomes in predominantly hepatitis B Asian patients treated with (90)Y-RE focusing on overall survival (OS), time to progression (TTP), tumor response, pattern of tumor recurrence and adverse events. Prognostic factors for survival were also identified. A retrospective cohort study was conducted in a single tertiary institution. All non-trial patients treated with (90)Y-RE at our institution from 1 January 2008 to 30 June 2012 were included. Data from 103 consecutive patients were analyzed. The majority of patients were Child-Pugh class A (59.2%) and Barcelona Clinic Liver Cancer (BCLC) stage C (68.9%). Median OS was 14.4months (95% CI 11.0-22.2), which varied by disease stage: Child-Pugh A, 21.7months; Child-Pugh B, 7.1months; BCLC B, 23.8months; BCLC C, 11.8months. Response and disease control rates by RECIST 1.1 were 21.2 and 59.6%, respectively, while disease control for index lesions treated with (90)Y-RE was 100%. Development of new intrahepatic lesions was the main reason for eventual disease progression. Median overall TTP was 5.3months (95% CI 4.1-10.0). Pretreatment vascular invasion, low serum albumin and elevated total bilirubin levels predicted poorer survival. Survival outcomes in hepatitis B Asian patients treated with (90)Y-RE for HCC are comparable to hepatitis C Western populations. While disease control for lesions treated with (90)Y-RE is excellent, the development of new lesions suggests a role for concomitant systemic therapy.