Abstract
BackgroundMalignant pleural mesothelioma (MPM) is a rare but aggressive tumor that originates from the pleura and has a poor prognosis. Eligible patients can benefit from surgery, but their survival is affected by many factors. Therefore, we created a graphic model that could predict the prognosis of surgically treated patients.MethodsWe retrospectively analyzed data from the Surveillance, Epidemiology, and End Results database from 2004 to 2014 to identify the key factors affecting the prognosis of surgically treated MPM patients. On this basis we built a nomogram to predict survival. We then evaluated the performance of the nomogram in a validation cohort.ResultsIn a training cohort of 828 cases, independent prognostic factors, including age, gender, histological type, differentiation, N stage, chemotherapy, type of surgery, and lymph node dissection, were identified. We then developed a nomogram to evaluate individual patient survival. In Kaplan–Meier analysis, a higher score in the nomogram was associated with a worse prognosis. We also used a validation cohort consisting of 312 patients to evaluate the performance of the nomogram, which was well calibrated and had good discrimination ability, with concordance indices of 0.715 and 0.656 for the training and validation cohorts, respectively.ConclusionThis study has improved our understanding of resected MPM and shown that key factors, including age and histological type, are associated with overall survival. The nomogram is a reliable tool that can help clinicians turn individualized prediction into reality and maximize patient benefit by identifying the most beneficial treatment approach.
Highlights
Malignant pleural mesothelioma (MPM) is a rare tumor that originates in the pleura; it is very aggressive and generally has a poor prognosis.[1–3] Surgery can be beneficial in patients who are healthy enough to tolerate it,[4–7] but postoperative survival varies, as many other factors play a role
A calibration plot for the nomogram for predicting one-year and three-year survival indicated that the nomogram has high predictive accuracy in the validation cohort (Fig 5b). This was the first large-scale study to analyze the prognosis of MPM patients who underwent surgery using a nomogram based on data from the SEER database
We developed a nomogram that could enable us to visually evaluate patient survival
Summary
Malignant pleural mesothelioma (MPM) is a rare tumor that originates in the pleura; it is very aggressive and generally has a poor prognosis.[1–3] Surgery can be beneficial in patients who are healthy enough to tolerate it,[4–7] but postoperative survival varies, as many other factors play a role. Wang et al built a nomogram based on data from the United States National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) database to. Methods: We retrospectively analyzed data from the Surveillance, Epidemiology, and End Results database from 2004 to 2014 to identify the key factors affecting the prognosis of surgically treated MPM patients. On this basis we built a nomogram to predict survival. Results: In a training cohort of 828 cases, independent prognostic factors, including age, gender, histological type, differentiation, N stage, chemotherapy, type of surgery, and lymph node dissection, were identified. The nomogram is a reliable tool that can help clinicians turn individualized prediction into reality and maximize patient benefit by identifying the most beneficial treatment approach
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
