Survival Analysis of TNBC Subtype Breast Cancer Based on Clinicopathology at Prof. Dr. I.G.N.G Ngoerah Hospital Denpasar

Abstract

Introduction: Triple-negative breast cancer (TNBC) is a subtype of breast cancer that has worse clinical outcomes and contributes to 30% of breast cancer deaths. Management targets focus on inhibiting progression and improving patient survival. Therefore, this study aims to identify factors that influence the survival of TNBC subtype breast cancer patients at Prof. Dr. IGNG Ngoerah Hospital Denpasar. Methods: This study used a retrospective cohort design, using medical record data and the Cancer Registry of TNBC subtype breast cancer patients who were treated at Prof. Dr. IGNG Ngoerah Denpasar Hospital from January 1, 2017, to December 31, 2021. The variables studied included age, menstrual status, tumor size, lymph node status, metastasis, tumor stage, tumor grading, lymphovascular invasion (LVI), and tumor-infiltrating lymphocyte (TIL). Data analysis was performed using Kaplan-Meier and Cox regression methods. Result: A total of 113 patients were included in this study. The majority of patients were >40 years old (85%). The median survival of TNBC subtype breast cancer patients was 42 months (95% confidence interval [CI] = 38.31-46.32). Factors associated with TNBC subtype breast cancer patient survival were T stage (hazard ratio [HR] = 3.10; 95% CI = 1.393-6.904; p=0.006), N stage (HR=1.56; 95% CI=1.003-2.443; p=0.048), metastasis (HR=4.07; 95% CI=2.310-7.191; p<0.001), and tumor stage (HR=1.57; 95% CI=1.312-1.897; p<0.001). Age, menstrual status, tumor grading, LVI, and TIL were found to have no significant effect on patient survival. Conclusion: Age, tumor size, lymph node status, metastasis, stage, grading, and LVI are factors that influence the survival of TNBC subtype breast cancer patients in TNBC subtype breast cancer patients treated at Prof. Dr. IGNG Ngoerah Hospital Denpasar.