Survival after Stevens‒Johnson Syndrome or Toxic Epidermal Necrolysis: A United Kingdom‒Based Cohort Study

Abstract

Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare mucocutaneous adverse drug reactions (Ferrandiz-Pulido and Garcia-Patos, 2013; Frey et al., 2017a, 2017b; Harr and French, 2012; Hsu et al., 2016; Martín-Merino et al., 2015; Mockenhaupt, 2012; Mockenhaupt et al., 2005). In the European Registry of Severe Cutaneous Adverse Reactions, 23% of patients died within 6 weeks after the onset of SJS and/or TEN (SJS: 12%, SJS and TEN overlap: 29%, TEN: 46%, 2003–2007). After 1 year, 34% of patients had died (Sekula et al., 2013).