Survival after recurrence following curative intent resection of pancreatic adenocarcinoma.

Abstract

e15760 Background: Limited data exist on outcomes after recurrence after curative intent resection for pancreatic adenocarcinoma (PC). We analyzed the prognostic significance of time to recurrence and associated factors in patients with post-pancreatectomy recurrence. Methods: Patients with a documented recurrence were identified from a prospectively maintained database of all patients undergoing pancreatectomy for PC between 2009-2015 at Indiana University Simon Cancer Center. Patients were divided into early (≤12 mos after surgery) and late recurrence ( > 12 mos after surgery) groups. Demographic (age, race, sex) and clinical (CA19-9, bilirubin, tumor location, diabetes at presentation, ECOG performance status, margin status, adjuvant radiation, and adjuvant and metastatic chemotherapy) data were obtained by manual chart abstraction and the IUSCC cancer registry. The primary outcome was survival after recurrence (SAR- time from recurrence to death). Chi-square was used for univariate analysis (except t-test for age). SAR was estimated with the Kaplan-Meier method and 95% CI. Cox proportional-hazard model was used for multivariate analysis (MVA). Results: Of 437 patients undergoing surgical resection for PC, 235 had documented recurrence. More patients had an early recurrence (ER) as compared to late recurrence (LR; 58.3% vs 41.7%). Median SAR was significantly shorter in ER vs LR patients (6.2 vs 8.6 months; HR, 0.71; 95% CI, 0.53-0.95; P = 0.02). Median age was higher in ER vs LR groups (64.7 and 64.2 years, P = 0.002). Diabetes at presentation was more common in ER vs LR group (42.3% vs 30.6%, P = 0.09). ER patients were significantly less likely to have received adjuvant chemotherapy (70.7% vs 84.7%, P = 0.02) or adjuvant radiation (17.8% vs 40%, P < .001). MVA showed a trend towards longer SAR in LR vs ER group (adjusted HR = 0.75, 95% CI, 0.55-0.1.03, p = 0.08) however age, adjuvant chemotherapy, adjuvant radiation and diabetes at presentation were not significant predictors of SAR. Conclusions: Early recurrence after resection of PC is associated with poor SAR. Patients with early recurrence tend to be older, diabetic at presentation and were less likely to have received adjuvant chemotherapy or adjuvant radiation.