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Abstract
Background Diabetes mellitus is recognized as one of the most common, serious, and costly chronic diseases. Opium addiction is also a common health problem in Iran. Given the high prevalence of opium use in South Khorasan Province and the increasing prevalence of opioid abuse in the community, this study was performed to investigate the effect of opioid abuse on the extent of disease in diabetic patients undergoing coronary angiography in the cardiology department of Vali-e-Asr Hospital in Birjand city, South Khorasan Province, Iran. Methods This study recruited a total of 1051 diabetic patients who underwent coronary angiography in the cardiology department of Vali-e-Asr Hospital of Birjand city from 2011 to 2015. The collected data were analyzed using SPSS version 22.0 with the chi-square test and univariate regression analysis. P value <0.05 was considered as statistically significant. Results Among opiate-addicted diabetics, the risk of coronary artery disease was 0.44 times higher than among nonaddicted diabetics (range 0.24–0.77, P=0.004). The extent of coronary vessel involvement, when present, was not different between the two groups. Conclusion Opiate-addicted diabetics appear to be more susceptible to CAD than their nonaddicted counterparts. The determinants and correlates of this interaction must be the subject of further study.
Highlights
Diabetes is a common, serious, and costly chronic disease in Iran [1]
In some regions of the world, especially in Asia and the Middle East, the use of opium has a protective effect on the control of CVDs, hypertension, and diabetes [4,5,6], which has driven higher rates of opium use in these areas. e prevalence of opium use is high in Iran, as 3% of the population is addicted to opium [6]
This checklist evaluated some variables such as age (e.g., 65 years old), gender, family history of CVD, opium use, dyslipidemia, history of hypertension, body mass index, diabetes, and extent of coronary vessel involvement. en, the subjects were assigned into three groups based on the extent of coronary vessel involvement as follows: the normal CAD group comprised of patients without any coronary involvement on angiography, the no significant CAD group comprised of patients with coronary involvement less than 50%, and the significant CAD group comprised of patients with coronary involvement more than 50%
Summary
Diabetes mellitus is recognized as one of the most common, serious, and costly chronic diseases. Opium addiction is a common health problem in Iran. Given the high prevalence of opium use in South Khorasan Province and the increasing prevalence of opioid abuse in the community, this study was performed to investigate the effect of opioid abuse on the extent of disease in diabetic patients undergoing coronary angiography in the cardiology department of Vali-e-Asr Hospital in Birjand city, South Khorasan Province, Iran. Is study recruited a total of 1051 diabetic patients who underwent coronary angiography in the cardiology department of Vali-e-Asr Hospital of Birjand city from 2011 to 2015. Among opiate-addicted diabetics, the risk of coronary artery disease was 0.44 times higher than among nonaddicted diabetics (range 0.24–0.77, P 0.004). Opiate-addicted diabetics appear to be more susceptible to CAD than their nonaddicted counterparts. Opiate-addicted diabetics appear to be more susceptible to CAD than their nonaddicted counterparts. e determinants and correlates of this interaction must be the subject of further study
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