Abstract

Following the licensure of two rotavirus vaccines in Europe, we aimed to assess factors, such as surveillance, disease burden and laboratory capacity, which will be relevant for making decisions about rotavirus vaccine introduction in the different countries. We conducted an email-based survey of the national public health bodies in the World Health Organization (WHO) European Region in 2006 and report here the results from the 23 countries in the eastern part of the region. The survey included questions on rotavirus surveillance, laboratory capacity, burden (in children under the age of five years) and intention to introduce rotavirus vaccination. Countries were grouped into the four per-capita income categories defined by the World Bank. Fourteen of the 23 countries responded to the survey. All except one country reported that less than a quarter of their laboratories had rotavirus diagnostic capacity. Four countries had some form of specific rotavirus surveillance, but half were of very limited coverage. Ten countries did not report data on the incidence of rotavirus hospital admissions, although nine were able to report some data on rotavirus burden. Six of the responding countries said they were likely to introduce universal rotavirus vaccination. Rotavirus surveillance and laboratory capacity in the eastern part of the WHO European Region is limited but most countries had some estimate of rotavirus burden, often from special studies. The reported mortality rates were lower than those from a WHO mortality data source. Many countries in the eastern part of WHO European Region face a number of challenges before vaccine implementation, including strengthening surveillance, improving laboratory capacity and addressing financial barriers.

Highlights

  • The recent publication of the results of phase III trials of two oral rotavirus vaccines [1,2] showed vaccines that were effective in preventing serious clinical end points of rotavirus infection

  • The survey was addressed to the person in the national public health body in each country who was responsible for national rotavirus surveillance

  • We found initially that the response rate for surveys sent from the United Kingdom (UK) was very low (9 of 26; 35%), and the results suggested that laboratory capacity and data on rotavirus burden was better in the western part than in the eastern part of the World Health Organization (WHO) European Region

Read more

Summary

Introduction

The recent publication of the results of phase III trials of two oral rotavirus vaccines [1,2] showed vaccines that were effective in preventing serious clinical end points of rotavirus infection. Following the licensure of both vaccines by the European Medicines Agency (EMEA) [4,5], there has been renewed interest in preventing rotavirus disease in Europe, with many countries considering the introduction of rotavirus vaccine into their routine immunisation schedule. The introduction of these vaccines will depend upon a number of country-specific factors. These include local disease burden (mortality and morbidity), diagnostic and surveillance capacity, cost of the vaccine (which is relatively expensive [6]), vaccine effectiveness and adverse events profile, as well as competing healthcare priorities. An additional influencing factor that was reported was the lack of laboratory capacity

Objectives
Methods
Results
Discussion
Conclusion
Full Text
Published version (Free)

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call