Abstract
Many ionization methods have been developed in the past decade for the analysis by mass spectrometry of non-volatile and thermally labile compounds with molecular weights ranging from 300 to 10,000 daltons. This process has taken place and still continues parallel with the progress made in liquid chromatography, a technique suited for dealing with such compounds. A combination of liquid chromatography and mass spectrometry is therefore a logical consequence. In this survey the principles of the ionization methods desorption chemical ionization, laser desorption, field desorption, electrohydrodynamic ionization, 252Cf plasma desorption, secondary-ion mass spectrometry, fast-atom bombardment, atmospheric pressure ionization and thermospray ionization are given together with applications reported in the literature. Some of these methods have the potential of being coupled directly to a liquid chromatograph through a suitable interface.
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