Survey of adult carotid atherosclerosis in historical endemic area of Kaschin-Beck disease in Heilongjiang province in 2009

Abstract

Objective To assess the prevalence of carotid atherosclerosis in adult patients with KaschinBeck disease（KBD） in endemic area, and to investigate the association between KBD and atherosclerosis. Methods B-mode ultrasound was used to investigate carotid atherosclerosis in patients with KBD over 40 years old in Shanhe farm and Shangzhi city and residents in Shuangcheng county in 2009. Ultrasonography images were saved and graded according to intima media morphology. Results The prevalence rates of carotid atherosclerosis in patients with KBD from the 5 villages affiliated to Shanhe farm were 50.0%（26/52）,37.3%（ 19/51 ）,42.5%（30/71 ）,58.2% （39/67） and 44.0% （22/50） , respectively. The prevalence rates of carotid atherosclerosis in patients with KBD from the 5 villages affiliated to Shangzhi city were 63.0% （34/54）, 45.3% （24/53）, 47.2% （25/53）, 60.0% （30/50）and 51.9% （28/54）, respectively. The prevalence rates of carotid atherosclerosis in people without KBD in the 5 control villages affiliated to Shuangcheng county were 63.9% （46/72）,43.1% （31/72）,57.1% （40/70）,46.9% （30/64） and 53.0%（35/66）, respectively. Ten villages in KBD endemic area and 5 villages in control area were investigated. The prevalence rates of carotid atherosclerosis in the 15 villages were standardized and compared by Wilcoxon test. The differences were not significant between two KBD endemic areas and one control（ T = 25.0,24.5,all P 〉 0.05）. There was no significant difference in prevalence of atherosclerosis in the 3 areas（x2 = 0.36, P〉0.05）. Comparing the severity of carotid atherosclerosis in 3 locations, the difference was statistically significant （x2 = 15.28, P 〈 0.05） and there was significant difference statistically between the subjects in Shangzhi city and that in the control group（x2 = 8.92, P 〈 0.05）. There was no significant difference between the detection rate of atherosclerosis and the severity of KBD, and similar results in the grade of atherosclerosis and the severity of KBD were found （x2 = 1.88,5.07, all P 〉 0.05）. Conclusions The prevalence rate of carotid atherosclerosis in historical endemic area in Heilongjiang province is not higher than that in the control area. Key words: Kaschin-Beck disease; Atherosclerosis; Ultrasonography