Abstract
Limited data are available describing extrapulmonary nontuberculous mycobacteria (NTM) infections in the general population. We describe results from statewide population-based laboratory surveillance in Oregon, USA, during 2007–2012. We defined a case of extrapulmonary NTM infection as >1 isolate from skin/soft tissue, disseminated sites, lymph node, joint, or other sites. The annual incidence of extrapulmonary NTM infection (other than Mycobacterium gordonae) was stable, averaging 1.5 cases/100,000 population. Median age of the 334 patients was 51 years, and 53% of patients were female. Half of cases were caused by M. avium complex, but rapid-growing NTM species accounted for one third of cases. Most extrapulmonary NTM infections are skin/soft tissue. Compared with pulmonary NTM infection, more extrapulmonary infections are caused by rapid-growing NTM species. the designation of NTM as a reportable disease in Oregon in 2014 will result in better detection of changes in the incidence and patterns of disease in the future.
Highlights
Limited data are available describing extrapulmonary nontuberculous mycobacteria (NTM) infections in the general population
Numerous case series are found in the literature, few data exist to describe the populationbased epidemiology of extrapulmonary NTM infections
We describe the results of a statewide laboratory surveillance study in Oregon, USA, that identified all patients from whom NTM was isolated from extrapulmonary sites during 2007–2012
Summary
Limited data are available describing extrapulmonary nontuberculous mycobacteria (NTM) infections in the general population. We defined a case of extrapulmonary NTM infection as >1 isolate from skin/soft tissue, disseminated sites, lymph node, joint, or other sites. The annual incidence of extrapulmonary NTM infection (other than Mycobacterium gordonae) was stable, averaging 1.5 cases/100,000 population. Most extrapulmonary NTM infections are skin/soft tissue. Compared with pulmonary NTM infection, more extrapulmonary infections are caused by rapid-growing NTM species. Nontuberculous mycobacteria (NTM) are ubiquitous in water and soil and are a cause of opportunistic pulmonary and extrapulmonary infections. Extrapulmonary manifestations include disseminated, skin, joint, and lymph node infections. We describe the results of a statewide laboratory surveillance study in Oregon, USA, that identified all patients from whom NTM was isolated from extrapulmonary sites during 2007–2012.
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