Abstract
There is debate about the role and optimal organisation of follow-up following treatment for primary breast cancer. We estimated using the best available evidence whether early detection by surveillance of ipsilateral breast tumour recurrence (IBTR) and metachronous contralateral breast cancer (MCBC) was cost-effective.
Highlights
Flat epithelial atypia (FEA) is seen with increasing frequency following biopsy of calcification detected through screening
In this series, one-view (MLO-alone) Digital breast tomosynthesis (DBT) had superior sensitivity compared with two-view 2D digital mammography (2DM)
To assess the diagnostic performance of computer-aided detection (CAD) for full-field digital mammography (FFDM) correlated with breast density assessed by an automated breast density measurement system (Hologic, Quantra) in breast cancers and age-matched healthy controls
Summary
Flat epithelial atypia (FEA) is seen with increasing frequency following biopsy of calcification detected through screening. Methods We randomised 867 women attending their final round of screening to receive the PEP Intervention or usual care, measuring breast cancer awareness at baseline and 1 year. We systematically reviewed the evidence of effectiveness of interventions to promote cancer awareness and early presentation. Results At 1 year, the intervention increased the proportion breast cancer aware compared with usual care (24% vs 4%; odds ratio = 15.2, 95% CI = 4.8 to 47.8). The systematic review found one randomised trial of a one-to-one intervention that showed a much smaller effect on breast cancer awareness. At Velindre, breast cancer patients are followed up for at least 10 years, with annual mammography underpinning the service. Methods Using the RIS and HIS electronic databases, follow-up mammograms over a 3-year period from 1 June 2006 to 31 May 2009 were collected and their report codes checked. Throughout the study, the participants visual search behaviour as well as their image manipulations were recorded
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