Surrounding Inhibition in Rat Somatosensory Cortex During Noxious Electrical Stimulation of the Sciatic Nerve

Abstract

Surrounding inhibition is a physiologic mechanism to focus neuronal activity. Here we applied optical imaging of intrinsic signal to observing the temporal-spatial characteristic of rat primary somatosensory cortex during graded electrical stimulation of the sciatic nerve (5 Hz, duration of 2 s, 0.5 ms pulse, 1 and 10 muscle twitching threshold). We found that the magnitude and change duration (time course) of the optical signal were larger and longer with the intensity raising. The spatial extent was also wider under noxious electrical stimulus. Meanwhile, we found the inverted optical signal changes in the regions surround the activated primary somatosensory cortex. This phenomenon was similar to the inhibition surrounding focal itcal events observed by optical imaging of intrinsic signal. It suggests the surrounding inhibition under noxious electrical stimulus was probably induced by the excess discharge of excited neurons or it may provide finer discrimination during the noxious stimulus and support the view that the role of somatosensory cortex in pain localization is to finely discriminate the stimulus site.