Surrogate Indexes of Insulin Resistance in Dairy Goats: Transitional Variation in Subclinical Hyperketonemia.

Siqi Liu,Jing Wen,Yezi Kong,Yan Huang,Baoyu Zhao,Yaoquan Liu,Jianguo Wang,Binyun Cao,Xiaoyan Zhu

doi:10.3390/vetsci8060102

Siqi Liu, Jing Wen + Show 7 more

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https://doi.org/10.3390/vetsci8060102

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Abstract

Background: Dairy goats are highly susceptible to subclinical hyperketonemia (SCHK) during the transition period. This study aimed to compare the variation in metabolic parameters and surrogate indexes of insulin resistance (sIR) between goats with SCHK and clinically healthy (HEAL) goats during the transition period. Methods: Twenty Guanzhong dairy goats were assorted to HEAL (n = 10) and SCHK (n = 10) groups according to the blood β-hydroxybutyrate (BHBA) concentrations. The blood samples were taken from the jugular vein of each goat at −3, −2, −1, 0 (partum), +1, +2, and +3 weeks relative to kidding to analyses GLU and INS. The sIR was calculated from blood metabolic parameters. Results: Compared with the HEAL goats, the insulin concentrations were significantly higher in SCHK goats during the first three weeks postpartum. The QUICKI, revised QUICKI (RQUICKI), and RQUICKIBHBA were significantly lower in goats with SCHK at 1 week postpartum, while the homeostasis model assessment-IR (HOMA-IR) was significantly higher. Conclusion: Goats with SCHK made more efforts through elevated insulin levels at early lactation than HEAL goats, thereby maintaining the normal glucose concentrations.

Highlights

The transition period, ranging from 3 weeks prepartum to 3 weeks postpartum, is vital to the health status and reproductive performance of dairy goats [1]
Hyperketonemia is known as lactation ketosis or pregnancy toxemia, which usually happens in early postpartum or late pregnancy [5]
The second step was to select these experimental goats by the litter size of singleton and allocate them to one of the following two groups according to their plasma blood β-hydroxybutyrate (BHBA) concentrations: subclinical hyperketonemia (SCHK) (n = 10; BHBA = 0.8–1.7 mmol/L) or HEAL (n = 10; BHBA < 0.8 mmol/L) [6,17,18]

Summary

Introduction

The transition period, ranging from 3 weeks prepartum to 3 weeks postpartum, is vital to the health status and reproductive performance of dairy goats [1] During this period, fetal growth and milk secretion lead to a sharp increase of energy demands. Subclinical hyperketonemia (SCHK) usually has no typical symptoms compared with clinical forms, but this metabolic disorder makes dairy goats more susceptible to other production diseases, such as mastitis and hypocalcemia [6]. This study aimed to compare the variation in metabolic parameters and surrogate indexes of insulin resistance (sIR) between goats with SCHK and clinically healthy (HEAL) goats during the transition period. Results: Compared with the HEAL goats, the insulin concentrations were significantly higher in SCHK goats during the first three weeks postpartum. Conclusion: Goats with SCHK made more efforts through elevated insulin levels at early lactation than HEAL goats, thereby maintaining the normal glucose concentrations

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