Abstract
Suriclone is a new anxiolytic drug belonging to the family of cyclopyrrolones. Chemically it is entirely different from the benzodiazepines, but it acts as a benzodiazepine agonist with very high affinity to a subgroup of benzodiazepine receptors or to a special conformation of these receptors. In the present cross-over study, 33 out-patients with a diagnosis of neurotic anxiety were treated with suriclone (mean dose 2 mg/day) and diazepam (25 mg/day) in two 6-week periods. Both drugs had a significant anxiolytic effect, but diazepam appeared to have a better effect within the first 2 weeks of treatment. On the other hand, the suriclone effect showed a tendency to increase over time in contrast to the effect of diazepam. Suriclone and diazepam had a different side effect profile: suriclone produced mainly dizziness, while diazepam caused sedation. It is suggested 1) that the observation of less anxiolytic effect of suriclone reflects the special affinity of this drug to a subgroup or a subconformation of ...
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