Abstract
Wound infections after abdominal surgery are still frequent types of nosocomial infections. Suture materials might serve as a vehicle for mechanical transport of bacteria into the surgical wound. To prevent the contamination of suture material in surgical wounds, triclosan-coated suture materials with antibacterial activity was developed. We here report a prospective randomized pathway controlled trial investigating the effect of triclosan impregnation of polydioxanone sutures used for abdominal wall closure on the rate of surgical-site infections. A total of 856 patients included in this trial underwent a standardized clinical pathway documented abdominal wall closure after abdominal surgery. Patients were randomized to have the fascia closed with either a 2-0 polydioxanone loop or a triclosan impregnated 2-0 polydioxanone loop. The primary outcome was the number of wound infections. Risk factors for poor wound healing were collected prospectively to compare the two groups. When a PDS loop suture for abdominal wall closure was used, 42 (11.3%) patients with wound infections were detected. The number of patients with wound infections decreased significantly to 31 when the PDS plus for abdominal wall closure was used (6.4%, P < .05). Other risk factors for the development of side infections were comparably in the two groups. This clinical pathway facilitated trial shows that triclosan impregnation of a 2-0 polydioxanone closing suture can decrease wound infections in patients having a laparotomy for general and abdominal vascular procedures.
Highlights
Wound infections after abdominal surgery are still frequent types of nosocomial infections
We here report a prospective randomized pathway controlled trial (NCT00998907) in which we investigated the effect of impregnating, with triclosanim, polydioxanone sutures used for abdominal wall closure on the rate of SSIs
967 patients operated per protocol 559 PDS PLUS, 408 patients developing SSI were treated conservatively (PDS II)
Summary
Wound infections after abdominal surgery are still frequent types of nosocomial infections. This clinical pathway facilitated trial shows that triclosan impregnation of a 2-0 polydioxanone closing suture can decrease wound infections in patients having a laparotomy for general and abdominal vascular procedures. Surgery j 2013 a trichlorophenolic antiseptic with a wide use in consumer products, is the latest antibacterial agent used in coating or impregnation of surgical sutures It demonstrated good bactericidal properties against many SSI-relevant bacteria in preclinical studies[12] and decreased wound infections in several randomized trials.[13,14] Other studies failed to demonstrate a protective effect either due to under powering of the trial[15] or due to a lack of control of confounding factors of wound infections.[16]. Data are given as absolute numbers, mean and SEM or as median (range) unless indicated otherwise
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
