Abstract

Introduction: Stroke-like migraine attacks after radiation therapy (SMART syndrome) is a recently described clinical entity characterized by transient hemispheric dysfunction in patients with a history of remote external beam radiation therapy to the brain. Clinically, it may appear that the patient has suffered a devastating stroke and can be associated with seizures as well. Complete neurologic recovery is usual. To date, there have been 25 suspected cases reported in the literature; none were precipitated by intracranial/skull base surgery. We present a case of SMART syndrome diagnosed immediately following craniotomy and resection of metastatic tumor arising from the dura of the floor of the middle cranial fossa after prior gamma knife radiosurgery (GKRS) and whole-brain radiotherapy (WBRT) in the distant past.

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