Abstract
One hundred patients were treated with 0.25 per cent kanamycin sulfate as an operative irrigant and were compared with 100 patients in whom saline was used as an irrigant. Serum and urine kanamycin levels and tests of renal function were obtained following the use of kanamycin sulfate in various urologic operations. Peak serum level occurred when intraperitoneal lavage was performed following ureteroileal diversion. Lowest levels were obtained in surgery of the bladder. Excellent results manifested by low incidence of wound infections and complications due to the drug warrant its application in urologic surgery, expecially when urinary contamination may be expected.
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