Abstract
Objective Investigating the surgical treatment for dysembryoplastic neuroepithelial tumor. Methods A total of 12 cases (7 males, 5 females, aged 4~36 years) of dysembryoplastic neuroepithelial tumors from 2010 to 2014 in Shanghai Blue Cross Brain Hospital were analyzed retrospectively, including 9 cases of temporal lobe tumor, 2 cases of frontal lobe tumor, and 1 case of parietal lobe tumor. The tumors and epileptogenic foci outside the lesions were resected under the guidance of electrocorticogram in all patients. Results The pathological examination showed that all the tumors were dysembryoplastic neuroepithelial tumors. All the patients had been followed up for 2 to 4 years. Epilepsy occurred in 2 patients and the others were seizure free after the surgery. No tumor recurrence occurred during the follow-up. Conclusion Dysembryoplastic neuroepithelial tumor is a benign tumor often causes intractable epilepsy, which can be controlled by the extended excision of the tumors and epileptogenic cortex under the guidance of electrocorticogram.
Highlights
Dysembryoplastic neuroepithelial tumours (DNET) are benign tumours of neuroglial origin and clinically characterized by early onset seizures
Eclampsia discharge monitored by electrode monitoring (ECoG) was located around the lesion in the operation. 9 cases of temporal lobe DNET patients underwent tumor plus hippocampal amygdala or standard anterior temporal lobectomy, and 2 cases of frontal lobe and 1 case of parietal lobe patients underwent low-power bipolarcortical thermal cauterization on the central cortex according to ECoG monitoring after tumor resection
9 cases of patients with temporal lobe epilepsy and 1 case of frontal lobe epilepsy patients with postoperative follow-up period without any form of seizures, seizure control to Engel I level, the other 2 patients with abnormal existence central discharge line cortex hot burning technique but there is still a seizure, 1 case of frontal lobe epilepsy characterized by the contralateral limb automatism, 1 patient with parietal lobe epilepsy show the contralateral limb tonic-closure seizures, attacks the preoperative reduction, seizure frequency reduced more than 50%, without conscious loss; According to Engel efficacy grading, 10 cases were cured (83.3%) and 2 cases were significantly improved (16.7%)
Summary
Pathological diagnosis : Dysembryoplastic neuroepithelial tumor (WHO I level), the pathology report (figure 5a and 5b): tumor cell diffuse distribution, a tiny bursa, micro capsule floating among ganglion cells, tumor with branching small blood vessels, circle cell nucler, cytoplasm is empty, no obvious abnormity. Electroencephalographies were reviewed at 3 months, 6 months, 1 year and 2 years after surgery: 6 cases of normal electroencephalogram, 4 cases of roughly. MRI examination reviewed at 2 years after surgery (figure 3) showed no tumor recurrence in all cases. A and B: The tumor showed a polycystic, low signal intensity on T1WI, no tumor occupying effect. C and D: The tumor showed a mixed signal intensity on T2WI, cystic degeneration has been seen in the tumor. A and B: The image was transverse T1WI of contrast enhancement, which showed no enhancement of the tumor. Median and high spike wave in the right frontal region and temporal region, spike and slow wave synchronous single shot, transient spike wave on the right side
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
