Abstract
Methods Surgically resected specimen (men n = 59; women n = 72, age 48 ± 15) from 111 TC (84.7%) and 20 AtC (15.3%) patients were studied. The histological type, T-status, N-status (TC 94 N0, 17 N1/2; AtC 16 N0, 4 N1), pTNM stage (TC-I n = 81, II n = 17, III+IV = 13; AtC-I n = 12, II-IV n = 8), surgery (55 simple lobectomies, 16 bilobectomies, 24 pneumonectomies (4 extended), 15 segmentectomies, 16 sleeve lobectomy (in 2 of them combined with sleeve resection of pulmonary artery), 5 sleeve resection of main bronchus), and immunohistochemical expression (on 64 TCs and 13 AtCs) of p-HspB5, Hsp27 and mTOR were evaluated. Kaplan-Meier, Wilcoxon, Cox regression analyses were the statistical methods used.
Highlights
The aim of study was to study the prognostic factors after surgery with curative intend for pulmonary carcinoid tumors - typical carcinoid (TCs) and atypical carcinoid (AtCs)
The histological type, T-status, N-status (TC - 94 N0, 17 N1/2; AtC - 16 N0, 4 N1), pTNM stage (TC-I n = 81, II n = 17, III+IV = 13; AtC-I n = 12, II-IV n = 8), surgery (55 simple lobectomies, 16 bilobectomies, 24 pneumonectomies (4 extended), segmentectomies, sleeve lobectomy, 5 sleeve resection of main bronchus), and immunohistochemical expression of p-HspB5, Hsp27 and mTOR were evaluated
Postoperative survival is significantly related to the histology type, N status, pTNM stage and mTOR expression
Summary
The aim of study was to study the prognostic factors after surgery with curative intend for pulmonary carcinoid tumors - typical carcinoid (TCs) and atypical carcinoid (AtCs). Surgical treatment for bronhial carcinoid tumors prognostic factors for long-term outcome D Petrov1*, D Marinova2, E Goranov1, Y Slavova2, G Yankov1
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