Abstract
Objective: To assess the outcome and overall survival of surgery for gallbladder cancer. Methods: A systematic literature search was performed in PubMed. The review question was structured in PICO format. Then, the search was conducted according to a certain research strategy and certain limitations. The titles and abstracts of all retrieved citations were assessed by two medical consultants, who decided which articles to read in full text. The selected full text articles were independently screened by the researcher and the two colleagues. In a consensus meeting, it was determined which articles fulfilled the pre-defined inclusion criteria and eligibility. Results: A total of four citations were identified as fulfilling the predetermined eligibility criteria (two prospective cohort studies and two retrospective studies), while 630 studies which did not fulfill the inclusion criteria were excluded. Conclusions: Optimal treatment of gallbladder cancer is still evolving. Radical surgery in combination with standardized lymph node dissection constitutes the cornerstone of the surgical treatment. Patients’ overall survival depends upon their tumor stage, levels of CA199, and tumor location in gallbladder. Key Words: Gallbladder cancer, Surgery, Survival, Systematic Review.
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