Surgical outcomes of re-excimer laser phototherapeutic keratectomy (re-PTK)

Osamu Hieda,Yo Nakamura,Chie Sotozono,Shigeru Kinoshita,Koichi Wakimasu

doi:10.1038/s41598-021-91121-6

Osamu Hieda, Yo Nakamura + Show 3 more

Open Access

https://doi.org/10.1038/s41598-021-91121-6

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Journal: Scientific Reports	Publication Date: Jun 1, 2021
Citations: 2	License type: open-access

Affiliation: Kyoto Prefectural University of Medicine

Abstract

To assess the surgical outcomes of re-excimer laser phototherapeutic keratectomy (re-PTK) for recurrent disease after initial PTK. Retrospective cohort study with historical comparison group. This study involved 56 patients who underwent re-PTK (mean follow-up period: 47.9 ± 36.2 months) at the Baptist Eye Institute, Kyoto, Japan. In all subjects, corrected-distance visual acuity (CDVA) before and after re-PTK was compared. Postoperative recurrence of corneal lesion with a decrease of CDVA of two lines or more was compared with postoperative best CDVA deemed as a significant relapse. The Kaplan–Meier method was used to compare the recurrence rate post-re-PTK with that after the initial PTK. The disease classification in the 78 eyes was heterozygous-type GCD (hetero-GCD, n = 47 eyes), homozygous-type GCD (homo-GCD, n = 13 eyes), band keratopathy (n = 7 eyes), lattice corneal dystrophy (n = 6 eyes), and other (n = 5 eyes). After re-PTK, homo-GCD recurred statistically significantly earlier than hetero-GCD (P = 0.0042). No significant difference was found in the recurrence rate for all diseases between post-re-PTK and post initial PTK (P > 0.05). Surgical outcomes after re-PTK were nearly equal to those after initial-PTK.

Highlights

To assess the surgical outcomes of re-excimer laser phototherapeutic keratectomy for recurrent disease after initial Phototherapeutic keratectomy (PTK)
When cataract progression occurred during the post-rePTK period, cataract surgery was performed, and if the corrected-distance visual acuity (CDVA) decrease remained at 0.2 or more logarithm of the minimum angle of resolution (logMAR) lower than the highest CDVA after re-excimer laser phototherapeutic keratectomy (re-PTK), we identified it as a recurrence
Dashes in GCD2 appear whiter and rarely cross each other, and these signs can be distinguished from the lattice lines in lattice corneal dystrophy (CD) (LCD)

Summary

Introduction

To assess the surgical outcomes of re-excimer laser phototherapeutic keratectomy (re-PTK) for recurrent disease after initial PTK. There have been a few reported case studies on the outcomes of PTK after the recurrence of the corneal pathology post initial-PTK7,8 and k eratoplasty[9,10]. A few previous studies have reported adverse events resulting from PTK being performed multiple times[11,12], and to the best of our knowledge, there have been no published reports on the differences in the recurrence rate between the initial PTK and a re-excimer laser PTK (re-PTK). The purpose of this retrospective study was to investigate and assess the surgical outcomes and statistically analyze the rate of disease recurrence following re-PTK

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Results

Conclusion