Abstract
ObjectiveTo evaluate surgical outcomes and prognostic factors for T4 gastric cancer treated with curative resection.MethodsBetween January 1994 and December 2008, 94 patients diagnosed with histological T4 gastric carcinoma and treated with curative resection were recruited. Patient characteristics, surgical complications, survival, and prognostic factors were analyzed.ResultsPostoperative morbidity and mortality were 18.1% and 2.1%, respectively. Multivariate analysis indicated lymph node metastasis (hazard ratio, 2.496; 95% confidence interval, 1.218–5.115; p = 0.012) was independent prognostic factor.ConclusionsFor patients with T4 gastric cancer, lymph node metastasis was associated with poorer survival. Neoadjuvant chemotherapy or aggressive adjuvant chemotherapy after radical resection was strongly recommended for these patients.
Highlights
Radical resection had been proved to be the most important indicator of long-term survival for patients with gastric cancer, curative resection for locally advanced gastric cancer, defined as T4 in which the tumor perforates serosa (T4a) or invades adjacent structures (T4b), was associated with increased postoperative morbidity and mortality. [1] With improved surgical technique and early detection of gastric cancer, the prognosis of gastric cancer patients has been gradually improved
It is essential to clarify the incidence of postoperative morbidity and mortality in T4 gastric cancer patients who undergo curative operations, and to determine the prognostic factors in such populations
We retrospectively evaluated surgical outcomes and prognostic factors for T4 gastric cancer treated with curative resection
Summary
Radical resection had been proved to be the most important indicator of long-term survival for patients with gastric cancer, curative resection for locally advanced gastric cancer, defined as T4 in which the tumor perforates serosa (T4a) or invades adjacent structures (T4b), was associated with increased postoperative morbidity and mortality. [1] With improved surgical technique and early detection of gastric cancer, the prognosis of gastric cancer patients has been gradually improved. Radical resection had been proved to be the most important indicator of long-term survival for patients with gastric cancer, curative resection for locally advanced gastric cancer, defined as T4 in which the tumor perforates serosa (T4a) or invades adjacent structures (T4b), was associated with increased postoperative morbidity and mortality. [1] With improved surgical technique and early detection of gastric cancer, the prognosis of gastric cancer patients has been gradually improved. The prognosis of patients with T4 gastric carcinoma remained poor. It is essential to clarify the incidence of postoperative morbidity and mortality in T4 gastric cancer patients who undergo curative operations, and to determine the prognostic factors in such populations. We retrospectively evaluated surgical outcomes and prognostic factors for T4 gastric cancer treated with curative resection
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
