Surgical Outcomes and Fusion Rate Following Spinal Fusion in Patients with Chronic Kidney Disease: Impact of Kidney Function

Abstract

To evaluate surgical outcomes and fusion rate following spinal fusion surgery in patients with chronic kidney disease and assess the impact of kidney function. From March 2017 to February 2021, 54 consecutive adult patients with chronic kidney disease who underwent spinal fusion surgery were enrolled. According to the glomerular filtration rate (GFR) categories, 35 and 19 patients were classified into the non-end-stage renal disease (ESRD) group (GFR categories 3a-4; eGFR, 15-59mL/min/1.73m2) and ESRD group (GFR category 5; eGFR, <15mL/min/1.73m2), respectively. Baseline characteristics did not differ between the groups. The lumbar and thoracolumbar spines were the most operated. The mean number of fused vertebrae (4.9±2.3 vs. 4.1±2.0, P=0.122), operative time (228.4±129.6min vs. 160.5±87.5min, P=0.113), and surgical bleeding (743.1±630.5mL vs. 539.5±384.4mL, P=0.354) did not differ between the groups. However, occurrence rates of medical complications (25.7% vs. 52.6%, P=0.048) and 3-month readmission (8.6% vs. 35.3%, P=0.045) were significantly different between the groups. While the 3-month mortality (10.5% vs. 2.9%, P=0.28) and pseudarthrosis rates (35.3% vs. 9.1%, P=0.047) were higher in the ESRD group, the difference was not statistically significant for the former entity. Surgeons should consider the possibility of high morbidity and pseudarthrosis associated with spine surgeries when operating on patients with ESRD.