Surgical outcome of deep brain stimulation of subthalamic nucleus with beta oscillation in PD patients

Abstract

Objective the aim of this study is to observe therapeutic effect of subthalamic nucleus deep brain stimulation (STN-DBS)for parkinsonian patients with beta neural oscillation pattern in subthalamic nucleus.Methods Clinical data of 6 parkinsonian patients underwent STN-DBS were analyzed retrospectively.The UPDRS-Ⅲ and levodopa equivalent doses (LEDD) were recorded preoperatively and 1,6,12 months postoperatively.Results As compared with base line,the patients' UPDRS-]]Ⅲ at 1 month,6 months and 12 months after operation while off medication/on medication improved by 28.1％/33.4％,50.4％/48.7％ and 57.7％/56.6％ (P ＜ 0.01).UPDRS-Ⅲ rigidity subscore improved by 50.4％/44.9％,66.7％/50.3％ and 74.4％/54.5％ (P ＜ 0.01).UPDRS tremor subscore improved by 10.7％/8.3％,20.7％/38.9％ and 29.0％/38.9％ (P ＜ 0.05).The dose of dopaminergic treatment were reduced with reductions of 53.8％,60.8％ and 64.5％ (P ＜ 0.01),compared with baseline.Conclusions STN-DBS could effectively improve the movement symptoms of patients with beta neural oscillation pattern in subthalamic nucleus.Rigidity improvement was more obvious than tremor improvement after surgery.Dopaminergic medication could be reduced prominently after surgery. Key words: Subthalamic nucleus ; Deep brain stimulation ; Parkinson's disease ; Beta oscillation