SURGICAL MARGIN STATUS FOR RADICAL PROSTATECTOMY IN PATHOLOGICAL STAGE T2 DISEASE: A POPULATION-BASED STUDY

Abstract

four IL10 SNPs (rs3024496, rs3024509, rs1800896, rs1800872). Also associated with recurrence were one of three SOD2 SNPs (rs5746136: wt/var 1.38 (1.04-1.82), var/var 2.11 (1.26-3.53), p-trend=0.0008), one of 15 NOS2 SNPs (rs10459953: wt/var 1.38 (1.05-1.82), var/var 1.34 (0.85-2.10), p-trend=0.05), two of five CRP SNPs (rs1205: wt/var 0.65 (0.49-0.86), var/var 1.21 (0.76-1.94), p-trend=0.27; rs1800947: wt/var 0.50 (0.33-0.75), p=0.004), one of three IL1RN SNPs (rs878972: wt/ var 0.84 (0.64-1.11), var/var 0.54 (0.31-0.96), p-trend=0.03), one of one IL1B SNP (rs1143627: wt/var 0.80 (0.60-1.06), var/var 0.54 (0.36-0.81), p-trend=0.003), and one of one GSTP1 (rs1695: wt/var 1.40 (1.06-1.86), var/var 1.35 (0.84-2.16), p-trend=0.04). None of two TLR4, two SOD1, three SOD3, five MPO, two HOGG1, two GPX1, eight GSR, four IL6, one IL8, or six NOS3 SNPs was associated with recurrence. CONCLUSIONS: This is the first large study of genetic variation and risk of prostate cancer recurrence nested in a cohort. SNPs in genes involved in the immune response and oxidative stress were associated with risk of prostate cancer recurrence in men surgically treated for clinically localized prostate cancer, independent of known prognostic indicators pathologic stage and grade.