Surgical Management of Early Hepatocellular Carcinoma

Abstract

Abstract Background Hepatocellular carcinoma (HCC) is the most common primary hepatic malignancy ranking sixth in the world among all malignancies and becoming the third cause of death due to cancer. Incidence has increased all over the world, mainly because of increase in the incidence of chronic hepatitis B (HBV) and hepatitis C (HCV) infections Objective To study hepatocellular carcinoma in terms of pathogenesis, staging and diagnosis as well as discuss its surgical management and follow up afterwards. Patients and Methods Design: Prospective, comparative study. Setting: NHTMRI (national hepatology and tropical medicine research institute). Study duration: Period 3 years from April 2017 - April 2020. Patients: A total of 50 early HCC patients enrolled in the study. Results After applying (Forward method) and entering some predictor variables; the increase in operative time; had an independent effect on increasing ICU stay (p < 0.01). After applying (Forward method) and entering some predictor variables; the increase in age and operative time; had an independent effect on increasing drain removal days (p < 0.05 respectively). Conclusion Laparoscopic liver resection (LLR) is now considered a feasible alternative to open liver resection (OLR) in selected patients. Nevertheless studies comparing LLR and OLR are few and concerns remain about long-term oncological equivalence. LLR has short-term advantages and seemingly equivalent long-term outcomes and can be considered a feasible alternative to open surgery in experienced hands.