Surgical excision of corneal and coniunctival lesions combined with cryotherapy in the treatment of Mooren's ulcer

Abstract

Objective To discuss the efficacy of surgical excision of corneal and conjunctival lesions combined with carbon dioxide cryotherapy for the treatment of Mooren's ulcer.Methods 16 cases ( 17eyes) were underwent surgical excision of corneal lesions and conjunctival tissues adjacent to ulcer,followed with carbon dioxide cryotherapy,immunosuppressive agents were administered until the ulcer healed.All the cases were followed up for 1 to 5 years.Results None of the cases had infection and deterioration during therapy.7 cses (7 eyes) cured after combined therapy once,cryotherapy 4cases(4eyes) cured after repeated carbon dioxide cryotherapy 4cases (4 eyes) appeared to recurrent attacks,yet no recurrence was detected after repeated combined therapy.2 eyes appeared to recurrent attacks,and accepted the corneoscleral lamellar graft.Conclusion The surgical excision of corneal and conjunctival lesions combined with cryotherapy is effective to treat Mooren's ulcer.The key procedure is excising the lesion tissues completely and mastering the appropriate temperature,time and frequency in cryotherapy. Key words: Corneal ulcer,Mooren's; Surgical excision; Cryocoagulation